The patient complains of gnawing, burning and twitching pain in the stomach especially when he is fasting, or he may experience pain typically 2 or 3 hours after eating food. Usually, the patient wakes up at night with pain. He takes the small quantity of food like biscuits or cold milk. Eating food in small quantity relieves the pain and again the patient goes to sleep. This is the most characteristic symptom described by the patients affected with H. Pylori infection.